For thousands of years physicians knew that the urine of diabetic patients tasted and smelt sweet
In a randomized, double-blind, placebo-controlled crossover trial of 30 adults with obesity (Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity, Blundell and colleagues, Diabetes, Obesity and Metabolism , 2017), 12 weeks of once-weekly semaglutide titrated to 1.0 mg was associated with less hunger, fewer food cravings, better control of eating, and a lower preference for high-fat foods
GLP-1 drugs interact with brain regions that regulate wakefulness
Journal of Clinical Endocrinology and Metabolism, 105(8), e2710-e2716
Results are visible soon after treatment, though mild swelling may occur before the outcome settles
Minimize physical and emotional stress through sleep optimization (79 hours nightly) and stress-management practices, since cortisol elevation further accelerates telogen effluvium
