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Researchers should establish baseline data for each compound individually before assessing combinatorial effects, and all protocols should follow applicable institutional research guidelines

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The EMPA-REG OUTCOMES trial showed that empagliflozin, a SGLT-2i, markedly reduced the risk for HF hospitalization relative to the placebo ( HR = 0.65, 95% CI 0.500.85, P = 0.002) [96]

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