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Eli Lilly medical information specifically notes that tirzepatide has not been studied in patients with severe GERD, so close monitoring is warranted in this population

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The medication is injected into areas with a layer of subcutaneous fat, such as the abdomen, thigh, or upper arm

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This suggests that the antiatherosclerotic effects of short-term GLP-1 may not play a central role in atherosclerosis

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