A review of B vitamins and one-carbon metabolism highlights the importance of vitamin B12 and folate in the methylation cycle to generate methyl groups for use in DNA synthesis, amino acid homeostasis, antioxidant generation, and epigenetic regulation
Approximately one year later, he experienced a severe worsening of his previously very mild neuropathy, and lab evaluation yielded a serum B12 of 220 pmol/l (which is normal, remember!?), but an elevated serum MMA of 1300 nmol/l, supporting the existence of true B12 deficiency
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Both B12 shots and IV infusions bypass the gastrointestinal tract entirely, eliminating this dose-dependent absorption loss
The typical dosage is 1,000 mcg per injection, although this may be adjusted based on your individual health needs and goals
not intended as therapeutic claims
