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Importantly, an additional experiment showed that LASSS-treated BSA (after the removal of un-reacted LASSS) exhibited nitration resistance to the optimal peroxynitrite-treatment (1:2000 ratio), as shown in supplementary Figure 2, suggesting a model that LASSS-induced chemical modification mechanism exerts a nitration-inhibitory effect on a wide range of proteins susceptible to tyrosine nitration

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In some patients, results are seen at 4 weeks, occasionally faster

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doi: 10.1096/fj.15-275404 24 VeskoukisASTsatsakisAMKouretasD