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This work was supported by the Science and Technology Project of the Shandong Geriatrics Society (LKJGG2024Z003)

Initial fears of pancreatitis and thyroid cancer have not been substantiated by large-scale analyses or rigorous FDA/EMA evaluations [65, 68, 69] (e.g., human thyroid tissue lacks GLP-1 receptor expression)

The P appBA /P appAB efflux ratio (ER) was calculated

A meta-analysis of clinical trials, including data from Novo Nordisk itself, found higher incidence of optic ischemic neuropathy in GLP-1 groups compared to placebo

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