In both in vitro and in vivo rodent studies, BPC-157 induces early expression of EGR-1 and its corepressor NAB2, forming a regulatory feedback loop that modulates the duration and amplitude of angiogenic gene transcription during wound healing, which suggests BPC-157 may engage feedback mechanisms to prevent excessive angiogenic signaling [56]
Unknown long-term effects of injectable use: There simply isn't long-term safety data for subcutaneous GHK-Cu used repeatedly over years
& Macias, W
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[PubMed] [Google Scholar] 27.Molloy T.J., Wang Y., Horner A., Skerry T.M., Murrell G.A