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However, in the 25 to 33% of patients who experience shunting with thiopurine monotherapy (preferential metabolism to less effective and potentially toxic thiopurine metabolites), low doses of thiopurines in combination with allopurinol may be prescribed to improve therapeutic effect

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For researchers exploring complementary metabolic pathways, compounds like Tesofensine (a monoamine reuptake inhibitor studied for appetite regulation) or MK 677 (a growth hormone secretagogue) address different aspects of energy metabolism and body composition

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