"Perhaps doses that achieve modest weight loss but robust anti-inflammatory and vascular benefits might be appropriate for some indications, while maximum-tolerated doses remain appropriate for obesity," says Nadolsky
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But you still need to eat in a calorie deficit for weight loss, choose nutrient-dense whole foods most of the time, get regular physical activity including both cardio and strength training, get adequate sleep since poor sleep disrupts appetite hormones, manage stress as chronic stress elevates cortisol and promotes fat storage, and address emotional or behavioral eating patterns
Dosing Strategies for Weight Loss Weight Loss Results with Retatrutide Phase 2 trial results by dose: 1mg produced 8.7% weight loss, 4mg hit 17.3%, 8mg reached 22.8%, and the 12mg group lost 24.2% at 48 weeks