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Gradually introducing this drug may give the best chance of positive long-term results for controlling diabetes and achieving healthy weight goals

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Engaging all three pathways simultaneously drives glucose-dependent insulin secretion through the two incretin arms while adding glucagon-receptor agonism implicated in energy expenditure, the pharmacological rationale that distinguishes it from single (GLP-1 (Sema)) and dual (GLP-2 (Triz)) incretin agonists

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doi: 10.3389/fnins.2019.01310 176 MillerT