Tirzepatide's dual-agonist profile is documented across the SURPASS clinical-trial programme (e.g
The expression of GLP-1 and/or GLP-1R was found in hypothalamic feeding centers (28, 29), hindbrain matrix (30), the lateral parabrachial nucleus of the posterior nucleus (31), and mesolimbic substrates (3234), etc
By simultaneously targeting all three receptors, retatrutide is hypothesised to deliver additive effects on appetite suppression, insulin secretion, and energy expenditure
We present clinical strategies for adverse event mitigation, monitoring recommendations, contraindications, and practical considerations for treatment discontinuation or switching
Authors contributions Writing and revising the manuscript (YH), assisting with the writing of the manuscript (CS, YC, YDL), supervising and revising the manuscript (JGF)
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