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coli by BMDCs leads to an increase in MHC-II, CD86, and CCR7, as well as the production of IL-6, IL-23, and IL-1 [35]

While early studies centred on cases obtained from institutionalised psychiatric settings [92, 93, 98], cases were later recruited through internal research registers [64], multiple centres [47, 50, 64, 70, 71, 88, 95, 96] or community advertisements [75]

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We chose to focus on MRS profiling of the ACC and SMA because both have been previously implicated in the neural circuitry of compulsivity (see Introduction)

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