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The body has evolved intricate antioxidant defense mechanisms to mitigate the damage caused by free radicals

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Biochemical features Biochemical features in ferroptosis involve iron accumulation, lipid peroxidation, generation of ROS, and depletion of glutathione peroxidase 4 (GPX4)

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Lower glutathione peroxidase activity weakens the brain's ability to clear hydrogen peroxide and lipid peroxides, promoting reactive oxygen species accumulation and oxidative stress, which ultimately damages neurons (108, 109)

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