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Possible Side Effects Most reactions are mild and limited to the skin surface: Transient burning or stinging at application site Redness, dryness, or itching Acneiform eruptions or folliculitis Tingling or rash Contact dermatitis (rare) Management tips: Use a gentle cleanser, avoid alcoholbased toners, and apply noncomedogenic moisturizer if needed

Allows delivery without injections

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Illuminating redox biology using NADH- and NADPH-specific sensors

Only one patient had high urine level of 5-oxoproline

Enzymatic aspects