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J Pharmacol Exp Ther (2002) 302(3):8818

So maybe you can give us insight about that

Liraglutide is approved in Europe for patients with T2DM and mild or moderate kidney damage, but is currently not recommended or should be used with caution in patients with severe renal impairment (130)

Nowak, A

For example, the SURMOUNT-5 trial showed that tirzepatide (Zepbound) helped patients achieve roughly 20% weight loss, compared to 14% with semaglutide (Wegovy)