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36 , E1E150 (2015)

Long-acting agents, on the other hand, provide continuous receptor activation due to structural modifications that slow their absorption, reduce the rate of renal clearance or extend their half-lives [52, 53]

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& Jonscher, K

A potential future avenue includes long-acting analogues of LEAP2, a native antagonist of the ghrelin receptor, which may reduce food intake by attenuating ghrelin-mediated orexigenic and lipogenic signaling