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92% fat mass versus 8% lean mass in SURMOUNT-1, compared to 88% fat versus 12% lean in STEP trials

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These effects usually correlate with rapid blood sugar stabilization or mild dehydration rather than the medication itself

What it is: A once-weekly GLP-1 medicine for chronic weight management when combined with diet and activity How it works: Activates GLP-1 receptors in the brain and gut to reduce hunger and increase fullness What to expect: Many patients see steady weight loss over several months as the dose reaches a maintenance level Common considerations: Nausea, mild stomach discomfort, constipation, or diarrhea can occur during dose increases and usually improve with time and meal adjustments What it is: A once-weekly medicine that targets both GIP and GLP-1 receptors How it works: Adds a second pathway that further supports appetite control and metabolic health What to expect: Clinical studies have shown larger average weight reductions at higher doses compared with GLP-1 alone

References Marassi M, Fadini GP