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J Neuroimmune Pharmacol 21 , 12 (2026)

To evaluate the incidence of MACE-4 events in patients treated with tirzepatide compared to the control group, a meta-analysis was conducted using data from 7778 patients enrolled in the SURPASS-4 study, SURPASS Clinical Trails Program (which includes 7 randomized clinical trials), and SURMOUNT-1

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Together, these findings suggest that the risk is not theoretical: over-stimulation of the reproductive system can lead to measurable declines in sperm quality