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Metformin is dialyzable with a clearance of up to 170 mL/min under good hemodynamic conditions

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Interestingly, while oxyntomodulin-bound GLP-1R displayed a more similar TMD conformation to that bound to GLP-1 in the static cryo-EM structure, the effect of mutagenesis was more divergent, with numerous mutations differentially impacting oxyntomodulin affinity and/or signalling data relative to GLP-1 (Supplemental Figures 9-10, Supplemental Table 2)

As a fellow reproductive endocrinologist and infertility specialist i highly recommend this episode to anyone interested in the field of fertility and reproductive medicine