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The number and proportion of older adults who have MCI due to Alzheimer's disease are currently difficult to estimate because they require studies with both populationbased prevalence measures of MCI and tests of Alzheimer's biomarkers

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Although we cannot rule out that the increased production of ROS in 3D culture conditions may not be observed under hypoxia, it should be noted that hypoxia itself induces ROS production in numerous cell types, including tumor cells [39]

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