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Consider a patient in her mid-40s, call her Elena, who'd been seeing a dermatologist on the Upper East Side for a couple of years

doi: 10.1128/mbio.01108-25

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Increased levels of PRPP, in turn, drive enhanced de novo synthesis of purine nucleotides in excess of the needs of the body

-Synuclein undergoes different post-translational modifications such as phosphorylation, nitration, acetylation, o -GlcNAcylation ( N -acetylglucosamine attached through serine hydroxyl groups), truncation, and ubiquitination, and some of these may modify the aggregation, membrane-binding, metal-binding, and other properties of this protein (Oueslati, 2016

A review on laboratory liver function tests