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doi: 10.1016/j.ijbiomac.2014.08.007

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25,211,492 In addition to targeting fragile X syndrome, mGluR5 inhibition has been shown to salvage many phenotypes, including learning and memory deficits, social deficits, repetitive behaviours, hyperactivity, and dendritic spine dysmorphogenesis, in 16p11.2 deletion mice, BTBR mice and Shank3- knockout mice

Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimers disease

Cell viability and ROS and glutathione intracellular content of cells cultured in liquid medium were assessed by flow cytometry analysis of cells stained for 30 min in the dark with 0.025 M calcein-AM (ThermoFisher Scientific, C3099) at room temperature, 50 M Dichlorodihydrofluorescein-diacetate (DCFDA, ThermoFisher Scientific, D399) at 37 C, and 10 M monochlorobimane (ThermoFisher Scientific, M1381MP) at 37 C, respectively