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These symptoms typically appear early in treatment, with over 77% reported within the first month

ShantaramDRimaXYBradleyDLiuJZWrightVPAmariAet al

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Of note, the protein levels of NRF1, an upstream regulator of TFAM and one of the traditional targets of PGC-1, also showed a significant decrease

While these methods offer significant potential, their clinical translation is often hindered by the requirement for specialized equipment and the risk of skin irritation