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In KRAS-driven LC, targeting metabolic dependencies provides another strategic entry point

This overlap suggests that FOXO4s activation by oxidative stress and inflammation might follow similar mechanisms, pointing to a broader role of FOXO4 in stress and immune response contexts

Furthermore, tranilast has been investigated in Phase II clinical trials in combination with allopurinol for patients experiencing moderate-to-severe gouty arthritis

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However, the GSH redox system has not been studied in the retina from a mathematical modeling perspective