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Commonly used GLP-1 RAs include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity)

However, the medications also have significant side effects, including unintended muscle mass loss, nutritional deficiencies, a potential for increased risk of miscarriage or birth defects, and severe mental health issues like depression and suicidal thoughts

aleniglipron and orforglipron) are functionally Gs-biased and recruit -arrestin poorly (which is typically involved in turning off the GLP-1 receptor's signal by promoting internalization and downregulation and mediating nausea and vomiting)

Taking Januvia exactly as prescribed can also help prevent interactions

Spreading protein intake across 4-6 meals optimizes muscle protein synthesis

Philosophical acceptance of chronic treatment