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Prog Neuropsychopharmacol Biol Psychiatry 30 : 13671368

Excessive caffeine high caffeine intake is a recognised precipitant

Some estimates are even higher

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Though the structure was not publicly disclosed, AZD2820 was reported to be a partial hMC4R agonist (EC 50 = 1 nM, E max = 38%) and had no detectable agonist activity on hMC3R as shown in Table 1 ( ad libitum or were calorically restricted to induce 20% body weight loss prior to 12-week treatment with either 2.64, 10.8, or 53.4 nmol of AZD2820 per day via SC minipump infusion

The book also draws on interviews and observations from GLP-1 users describing what happens when appetite, food cues and old routines begin to reappear