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Loinard et al 61 have confirmed that phosphorylated eNOS is upregulated in CHOP / mice and CHOP binds to eNOS promotor, subsequently inhibiting NO production in endothelial cells

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Diagnosis of HSDD was confirmed using a standardized screening guide, and participants were required to have experienced acquired, generalized HSDD for more than six months, with prior normal sexual function for at least two years, and an ongoing willingness to engage in sexual activity at least once a month