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There is an urgent need for additional effective medicines, as the median survival rate is barely 35 years following diagnosis

The reduction of the NADP pool suggests that the electron influx into the NADP pool by metabolism more than compensates for the electron efflux to the anti-oxidant systems, and that glutathione reductase activity, catalysing the reduction of glutathione from NADPH, is limiting under the specific conditions of re-oxygenation after hypoxia

Cell Metab 25(1):152165

XJB-5-131 has a high affinity for TECs and reduces I/R-induced renal injury in mice by downregulating the expression of ACSL4 to inhibit ferroptosis

Glutathione is crucial for immune function, controlling inflammation, detoxification, skin health, cellular health, energy production and more

More widespread use of SGLT2i in type 1 diabetes will necessitate implementation of strategies to assess and mitigate DKA risk, including preventative measures, patient education and continuous ketone monitoring, as well as a better understanding of the potential benefits for clinical cardiorenal outcomes, especially in high-risk populations such as people with CKD (Table 2) [46, 47]