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GLP-1MK-801 also displayed superior weight loss efficacy compared with co-administration of GLP-1 and MK-801, despite having similar effects on food intake (Extended Data Fig

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Current evidence, including magnetic resonance imaging studies, suggests that skeletal muscle alterations resulting from GLP-1 RA-induced weight loss, such as enhanced insulin sensitivity and reduced muscle fat infiltration, are adaptive, thereby improving muscle quality despite concurrent reductions in lean mass [112]

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