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doi: 10.1007/s11064-016-2154-z, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 17.Szrok-Jurga S, Czumaj A, Turyn J, Hebanowska A, Swierczynski J, Sledzinski T, et al

Its visible human clinical development followed a very different route

2) Patterns should all be different in size

Since then, multiple guidelines and regulatory documents have addressed the issue, including a 1993 guidance on the study and evaluation of gender difference in clinical trial evaluation of drugs, which lifted restriction on participation by most women with childbearing potential (FDA, 1993, 2020b)