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GLP-1s are an approved treatment for those with a BMI over 30, or a BMI over 27 with at least one comorbidity like type 2 diabetes, hypertension or sleep apnea
Does that make it inferior
Oral GLP-1 formulations produce similar onset of appetite suppression, within one to four weeks, but achieve less total weight loss compared to injectable formulations
Unlike existing GLP-1 receptor agonists such as semaglutide (Wegovy, Ozempic) or dual agonists like tirzepatide (Mounjaro, Zepbound), Retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors simultaneously
The hormones produced by the enzymatic processing of proglucagon then play essential roles in glucose metabolism and homeostasis [8, 9]