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Importantly, we confirmed that hepatocyte Cyp2e1 protein levels were significantly lower in the presence of GLP-1R agonism in both the control and ethanol consumption group (Fig

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In particular, phosphorylation of AKT, a key effector for insulin signaling, appears to be significantly decreased, hindering the post-receptor signaling cascade downstream of insulin receptor substrate-2 (IRS-2) [112]

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