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Depending upon cell type BH 4 can be generated by several different (alternative) de novo biosynthesis pathways as well as by two different salvage pathways
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Diselenide bonds enhance efficacy via ROS generation, while Pt(IV) prodrugs are reduced to active Pt(II) by GSH, overcoming cisplatin limitations
BMC Endocr Disord 25(1):270 Su B, Luan ZL, Liu H, Tuomilehto J, Ji X