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[10] [12] The administration of Ascorbic Acid (Vitamin C) Injection is generally well tolerated, but adverse effects may occur, particularly at high doses or with prolonged use

Glutathione also plays a key role in supporting liver function and may help prevent or manage nonalcoholic fatty liver disease by protecting the liver from oxidative stress and fat build-up

Despite that UPR helps cells to cope with ER stress, prolonged ER stress induces apoptotic cell death where the accumulation of unfolded protein in ER results in increased expression activating transcription factor 4 (ATF-4) that in turn increases the transcription of the proapoptotic protein, C/EPB-homologous protein-10 (CHOP-10) (Li et al., 2014)