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In various tumor types, p53 mutations not only result in the loss of its tumor suppressor function but may also confer new oncogenic functions to the mutated p53, a phenomenon termed gain-of-function (GOF) ( The p53 protein plays a crucial role in cell cycle regulation and apoptosis

PubMed: (peer-reviewed) Nguyen T, et al

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Isotretinoin is a highly effective treatment for severe acne, but it requires careful management to avoid harmful interactions

Proteomic identification typically employs biotin-switch assays or differential labeling techniques, followed by enrichment and MS identification (Wolhuter and Eaton, 2017)