406 When GLP-1R is knocked out in astrocytes, it activates an integrated stress response, which affects the overall metabolic state by increasing the production of FGF21
Ltd., ProKidney, Roche, Vera, GSK, and Eli Lilly and Company
10.1038/nrendo.2015.51 36
These filings are part of a larger trend involving similar drugs like Wegovy and Mounjaro
But the evidence supports real, clinically meaningful benefits for many people with T1D: less insulin needed each day, flatter post-meal glucose curves visible on your CGM, meaningful weight loss where relevant, and based on emerging data potentially significant long-term protection for the heart and kidneys
Which one to choose depends on your individual diabetes diagnosis, current blood sugar levels, weight loss goals & what youre trying to achieve overall with your treatment