Copays for as little as $25 eligibility varies based on insurance, manufacturer coupon, dose and brand
Dulaglutide (Trulicity) injection [package insert]
For example, the STEP 1 trial of once-weekly semaglutide (2.4 mg) in people without diabetes achieved a ~15% average body weight reduction over 68 weeks (source), with a mean baseline BMI of ~38 (source)
The vast majority came from people eating less because their appetite was suppressed
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Some people may also notice that alcohol or spicy foods make symptoms such as nausea, heartburn, or acid reflux worse, although tolerance varies from person to person