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d , In vitro stability assay of GIPMK-801 ( n = 2) incubated in human plasma or PBS, pH = 7.4 ( n = 1)

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Figure EV6 Metabolic characterization of A549shNRF2-/H460shNRF2-BIND rescue cell models

This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration

Metabolism 49 , 709717 (2000)