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Molecular docking (MOE), alanine-substituted peptide library screening, and surface plasmon resonance (SPR) revealed that BPC157 binds FBXO22 through its proline residue at position 3 (P3)

12,13 While certain genetic disorders (eg, Kallmann syndrome) are linked to impaired function of the hypothalamus or pituitary gland from birth, toxic exposures and other environmental factors, both in utero and later in life, are also known to interfere with the activities of the gonadotropic hormones

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doi: 10.1021/ol000173t 332 OglahMKMustafaYF