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This dual action of improving systemic insulin resistance and acting on brain insulin receptors makes GLP-1 RAs a unique treatment option for individuals with both conditions

Further characterisation of the GCG-like family of peptides led to the discovery of an endogenous GLP-1/glucagon co-agonist oxyntomodulin, named for its potent effect on stimulating oxyntic (parietal) cells of the stomach to produce gastric acid