The proposed mechanism involves transdermal absorption , whereby the active compound penetrates the skin's outer layers (stratum corneum) and enters systemic circulation via dermal capillaries
Neither tells the whole story
Yue X, Liang J, Gu F, Du D, Chen F
[5] [6] Some agents in this class (including liraglutide, semaglutide and dulaglutide) have demonstrated cardiovascular benefits in clinical trials, though specific benefits vary by individual medication
Science makes the distinction clearwhile GLP-1 therapies can help begin the journey, surgery often provides the enduring reset the body needs for long-term metabolic health and stability
Tirzepatide, a dual GIP/GLP-1 receptor co-agonist, also demonstrated significant efficacy in a phase II trial for MASH [6]