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KPV is a tripeptide from -MSH with genuinely interesting preclinical anti-inflammatory data, most notably in mouse colitis models where it is taken up by the intestinal transporter PepT1 and inhibits NF-B signaling

Compared with vehicle controls, GLP-1GIPLani yielded more than 5,411 differentially expressed genes (DEGs) in the liver, compared to only 913 and 57 DEGs induced by GLP-1GIP and Lani, respectively (Extended Data Fig

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Lancet Gastroenterol Hepatol 2023;8:20-30

Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)

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