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Pathogenic mutations in UPS components as direct drivers of neurodegeneration The indispensable role of the UPS in neuronal health is most clearly illustrated by familial forms of NDDs caused directly by mutations in UPS constituents

Sundelin, E., Jensen, J

ROS-induced alteration of sodium-potassium ATPase can then impair the efficient reversal of neuronal depolarization-induced electrochemical gradients, causing excitotoxicity

References Giudice LC, Kao LC

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