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Nausea (28% incidence): Most common in weeks 4-10 during dose escalation

Childrens developing brains are highly vulnerable to OS, due to greater immaturity of cells, higher oxygen consumption, and more unsaturated fatty acids(Ikonomidou & Kaindl, 2011)

Evidence that -calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization

Yang Z, Zhao Y, Li Y, Song L, Lin Y, Liu K, et al