In vivo administration significantly increases serum testosterone levels in aged mice, accompanied by elevated expression of key testosterone synthesis enzymes including 3-HSD and CYP11A1
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This post-translational modification is now recognised as a major mechanism of redox-regulated cell signalling, controlling the activity of transcription factors, kinases, phosphatases, and metabolic enzymes in response to the intracellular redox environment
Specifically, to assess basal analgesia, (i) the first assessment (time "0") was preceded by the application of morphine or saline 30 min before (time "-30 min"), then by the application of the gastric pentadecapeptide BPC 157 or naloxone or saline 20 min before (time "-20 min"), and finally, by the application of the saline 10 min before (time "-10 min")
Y.LehouxS.et al (2019)
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