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Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight

PMID: 34283517

Together with our structural data, these observations support our proposal that Y211-water interactions are important for the transport of carnitine

Its strong autoaggregation and adherence properties further support its role in chemoprevention and DNA protection (70, 71)

Before making a decision, it's crucial to consult with a healthcare professional to determine the most suitable option based on individual health status and preferences

Hepatology 69(6):24142426