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H.VaisarT.et al (2017)

We also assume that normally 10% of the cysteine, glycine, and glutamate, in the blood is taken up per hour by other cells and that an additional 25% of cysteine is converted to cystine

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Of note, in the SURPASS-4 trial, adjudicated major adverse cardiovascular events (MACE) were not increased with tirzepatide compared with insulin glargine over an extended follow-up period of 52 additional weeks after the main trial period of 52 weeks [21]

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Weight reduction had not plateaued in SURPASS-6, so longer follow-up could determine whether further reductions/withdrawals of insulin therapy are possible and whether additional benefits in terms of HRQoL can be achieved