If youd like to look at all the data from this study (including data on live birth rates, adverse events, IVF/ICSI), you can check out this post: Type of supplement: N-acetyl-cysteine*: increased pregnancy rates (8 RCTs, 1,590 women) Melatonin*: increased pregnancy rates (7 RCTs, 678 women) Vitamin E : no difference in pregnancy rates (1 RCT, 103 women) Vitamin C : no difference in pregnancy rates (2 RCTs, 899 women) L-arginine : no difference in pregnancy rates (2 RCTs, 71 women) Vitamin D : no difference in pregnancy rates (1 RCT, 52 women) Vitamin B : no difference in pregnancy rates (1 RCT, 102 women) Myo-inositol + folic acid : no difference in pregnancy rates (1 RCT, 94 women) CoQ10*: increased pregnancy rates (4 RCTs, 397 women) L-carnitine*: increased pregnancy rates (2 RCTs, 450 women) Note that N-acetyl-cysteine and L-carnitine both had significant heterogeneity (variability) in their studies, so its less clear if these are effective

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23431 (May 1, 2026), the FDA proposed to restrict large-scale 503B compounding of these medications, with a public comment period open through June 29, 2026