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Its limits are specific: it gives little weight to cumulative burden in younger people, and it can understate risk in those whose LDL-C looks reassuring but whose particle number does not

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You only need a referral if you have a complex medical history

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When activin A (527) and IL-21s (528) processes are dysregulated, it is hypothesised to promote autoimmune and inflammatory diseases, although a causal role is still not shown (527)