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Studies of CR focused on osteocyte responsiveness are lacking but may be essential to understand the cortical bone changes that are evident in mice and humans (Table 2)

Mounjaro and Zepbound are Lillys dual agonists that seem to surpass Novo Nordisks Ozempic and Wegovy in weight loss power

This assumes no unexpected safety signals emerge from ongoing trials

Supplement electrolytes proactively

Maintain adequate hydration, monitor blood glucose levels (treating hypoglycaemia if below 4.0 mmol/L), ensure nutritional adequacy with small frequent meals, and rise slowly from sitting or lying positions